The paper identifies uridine modifications in VSMCs linked to post-transcriptional regulation during atherogenic transitions using epitranscriptomic profiling.

Biochemistry and Biophysics Reports · Sep 28, 2026Peer-reviewedMolecular Biology

Deficiency of ZC3HC1 modulates vascular smooth muscle cell phenotype and increases neointima formation

Rédouane Aherrahrou, Tobias Reinberger, Julia Werner, Miriam Otto, Jaafar Al‐Hasani, Maria Loreto Muñoz Venegas, Xiaoke Yin, Manuel Mayr, Mete Civelek, Heribert Schunkert, Thorsten Kessler, Zouhair Aherrahrou

This study investigates how ZC3HC1 deficiency affects vascular smooth muscle cell behavior and neointima formation using in vitro and in vivo models.

Arteriosclerosis Thrombosis and Vascular Biology · Mar 12, 2026Peer-reviewedGenetics

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques.

Ernest Diez Benavente, Santosh Karnewar, Michele F. Buono, Eloi Mili, Robin J. G. Hartman, Daniek Kapteijn, Lotte Slenders, Mark Daniels, Rédouane Aherrahrou, Tobias Reinberger, Barend M. Mol, Gert Jan de Borst, Dominique P.V. de Kleijn, Koen H.M. Prange, Marie A.C. Depuydt, , Hester M. den Ruijter

The paper identifies sex-stratified gene regulatory networks in atherosclerotic plaques, showing female plaques are enriched with myofibroblast-like smooth muscle cell networks.

Arteriosclerosis Thrombosis and Vascular Biology · Aug 17, 2023Peer-reviewedBioinformatics

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.

Krishna G. Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N. Wolford, Elle M. Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas Marston, Frederick Kamanu, Ida L. Surakka, Loreto Muñoz Venegas, , Adam S. Butterworth

A coronary artery disease GWAS of 181,522 cases among 1,165,690 participants yields 241 associations (54 new); an eight-predictor consensus nominates 185 candidate causal genes, 94 with ≥3 predictors.

medRxiv · May 24, 2021 · PreprintGenetic & Genomic Medicine✦ In-depth digest

Qtlizer: comprehensive QTL annotation of GWAS results

Matthias Munz, Inken Wohlers, Eric Simon, Tobias Reinberger, Hauke S. Busch, Arne S. Schäefer, Jeanette Erdmann

Qtlizer annotates GWAS variants with gene expression and protein abundance QTLs, revealing limitations of current cis-distance thresholds and enriching for housekeeping genes.

Scientific Reports · Nov 24, 2020Peer-reviewedBioinformatics