Author

Andreas Ziegler

Universität HamburgORCID 0000-0002-8386-5397Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Raphael O. BetschartiD· 2 shared Raphael TwerenboldiD· 2 shared Stefan BlankenbergiD· 2 shared Tanja ZelleriD· 2 shared Alaa OthmaniD· 1 shared Alexandre Thiéry· 1 shared Anke FähnrichiD· 1 shared Axel KünstneriD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

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10 top collaborators · 20 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Raphael O. BetschartORCID

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3 papers

Recent·Most cited

Comprehensive analysis of the genetic variation in the LPA gene from short-read sequencing

Raphael O. Betschart, Georgios Koliopanos, Paras Garg, Linlin Guo, Massimiliano Rossi, Sebastian Schönherr, Stefan Blankenberg, Raphael Twerenbold, Tanja Zeller, Andreas Ziegler

The paper analyzes genetic variation in the LPA gene using short-read sequencing to predict LP(a) concentration, finding allele-specific KIV-2 CN provides better prediction than total CN.

BioMed · Jun 4, 2024Peer-reviewedGenetic & Genomic Medicine

Comparison of calling pipelines for whole genome sequencing: an empirical study demonstrating the importance of mapping and alignment

Raphael O. Betschart, Alexandre Thiéry, Domingo Aguilera‐Garcia, Martin Zoche, Holger Moch, Raphael Twerenbold, Tanja Zeller, Stefan Blankenberg, Andreas Ziegler

This study compares WGS pipelines, finding DRAGEN outperforms GATK in speed and accuracy for variant calling and mapping.

Scientific Reports · Dec 13, 2022Peer-reviewedBioinformatics

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Misa Hirose, Paul Schilf, Yask Gupta, Kim Zarse, Axel Künstner, Anke Fähnrich, Hauke S. Busch, Junping Yin, Marvin N. Wright, Andreas Ziegler, Marie Vallier, Meriem Belheouane, John F. Baines, Diethard Tautz, Kornelia Johann, , Saleh Mohamed Ibrahim

This study shows that high mitochondrial heteroplasmy in mice reduces lifespan and impairs glucose metabolism.

Scientific Reports · Apr 11, 2018Peer-reviewedGenetics