Matthew James Thomas

This study identifies PTX3 as a key antifibrotic factor secreted by fibroblasts that modulates epithelial repair in acute injury and exacerbates damage in chronic injury.

This study investigates ligand-specific AXL signaling in IPF, showing GAS6 promotes basal cell proliferation while PROS1 inhibits it, with implications for therapeutic targets.

This study compares OPG secretion and ECM remodeling in control and fibrotic lung fibroblasts under fibrotic conditions, finding opposite responses in matrix stiffness and collagen fiber properties.

In Silico Treatment evaluates animal models for disease relevance by simulating gene expression changes in humans, identifying suitable models and drug effects.

The paper uses spatial transcriptomics to identify novel pathologic niches in IPF lung tissue and their cellular composition and communication.