Author

Diana Santacruz

Boehringer Ingelheim (Germany)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Fidel RamíreziD· 4 shared Alec Dick· 3 shared Coralie ViolletiD· 3 shared Benjamin StrobeliD· 2 shared Christoph H. MayriD· 2 shared Matthew James ThomasiD· 2 shared Werner Rust· 2 shared Abigail P JarretiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMolecular Biology

Fidel RamírezORCID

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Author profile →

5 papers

Recent·Most cited

Metabolic mapping of the human solute carrier superfamily

Tabea Wiedmer, Shao Thing Teoh, Eirini Christodoulaki, Gernot Wolf, Chengzhe Tian, Vitaly Sedlyarov, Abigail P Jarret, Philipp Leippe, Fabian Frommelt, Álvaro Inglés‐Prieto, Sabrina Lindinger, Bárbara M. G. Barbosa, Svenja Onstein, Christoph Klimek, Julio Garcia Murias, , Giulio Superti‐Furga

The paper systematically evaluates the metabolic and transcriptional effects of SLC superfamily members, identifying new substrates and functional groups.

Molecular Systems Biology · May 12, 2025Peer-reviewedSystems Biology

AXL-GAS6/PROS1 Interaction: A Critical Switch Between Aberrant- and Healthy Repair Following Alveolar Lung Injury

Devona Soetopo, Christoph H. Mayr, Katrin Fundel‐Clemens, Fidel Ramírez, Coralie Viollet, Alec Dick, Werner Rust, Diana Santacruz, Yvette Hoevels, Christopher J. Applebee, Sam Legg, Anastasia Funk, Gisela Schnapp, Julian A. Padget, Benjamin Strobel, , Kerstin Geillinger-Kästle

This study investigates ligand-specific AXL signaling in IPF, showing GAS6 promotes basal cell proliferation while PROS1 inhibits it, with implications for therapeutic targets.

bioRxiv · Apr 7, 2025 · PreprintMolecular Biology

JUNB O-GlcNAcylation-mediated promoter accessibility of metabolic genes modulates distinct epithelial lineage in pulmonary fibrosis

Marie‐Therese Bammert, Meshal Ansari, Leoni Haag, Zuhdi Ahmad, Victoria Schröder, Joseph Birch, Diana Santacruz, Werner Rust, Coralie Viollet, Benjamin Strobel, Alec Dick, Florian Gantner, Holger Schlüter, Fidel Ramírez, Muriel Lizé, , Huy Quang Le

The paper identifies O-GlcNAcylation of JUNB as a regulator of promoter accessibility in metabolic genes, driving aberrant epithelial lineage in IPF.

Advanced Science · Dec 15, 2024Peer-reviewedCell Biology

Spatial Transcriptomic Characterization of Novel Pathologic Niches in IPF

Christoph H. Mayr, Diana Santacruz, Sebastian Jarosch, Charlotte Lempp, Lavinia Neubert, Berenice Rath, Jan C. Kamp, Danny David Jonigk, Mark Kühnel, Holger Schlueter, Jonas Doerr, Alec Dick, Fidel Ramírez, Matthew James Thomas

The paper uses spatial transcriptomics to identify novel pathologic niches in IPF lung tissue and their cellular composition and communication.

bioRxiv · Dec 13, 2023 · PreprintSystems Biology

Ultra-parallel ChIP-seq by barcoding of intact nuclei

Laura Arrigoni, H. Al-Hasani, Fidel Ramírez, Ilaria Panzeri, Devon Patrick Ryan, Diana Santacruz, N. Kress, Andrew Pospisilik, Ulrike Bönisch, Thomas Manke

This paper introduces a method for ultra-parallelized ChIP-seq using barcoded intact nuclei, enabling high-throughput analysis of chromatin-associated proteins.

bioRxiv · Mar 5, 2018 · PreprintGenomics