NeuroscienceeLifePeer-reviewed
Gain-of-function mutations in the UNC-2/CaV2α channel lead to hyperactivity and excitation-dominant synaptic transmission in Caenorhabditis elegans
Yung-Chi Huang, Jennifer K. Pirri, Diego Rayes…·Mark J. Alkema
This study identifies a gain-of-function mutation in the UNC-2/CaV2α channel in C. elegans that causes hyperactivity and excitation-dominant synaptic transmission by altering cholinergic and GABAergic transmission.
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