Christina A. Maat

This paper introduces coppaFISH 3D and CASTalign to enable transcriptomic identification of thousands of in vivo recorded neurons at scale.

The paper analyzes single-nucleus transcriptomes from brain and choroid plexus tissues of COVID-19 and influenza patients, identifying broad transcriptional dysregulation in multiple cell types and linking these changes to neurological symptoms.

VINE-seq yields 143,793 single-nucleus transcriptomes of human brain vascular and perivascular cells; 30 of the top 45 Alzheimer's GWAS genes are expressed there, many microglial in mice.

This study characterizes the molecular changes in the mouse hippocampus during the acute stress response using multiomic profiling and identifies rapid resolution of molecular events within 4 hours.

The paper uses 3D multicolor STED microscopy to study subcellular distribution of alpha-synuclein variants in Parkinson’s disease brains, revealing their association with pathology.