Author

Kruti Calcuttawala

Stanford Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Assay:scRNA-seq· 5 Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:database / resource· 1

Frequent Co-Authors

Nicholas Schaum· 5 shared Andreas KelleriD· 3 shared Davis P. Lee· 3 shared Fabian KerniD· 3 shared Margaret Windy McNerneyiD· 3 shared Róbert PálovicsiD· 3 shared Tony Wyss‐CorayiD· 3 shared Aaron M. KershneriD· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersNeuroscience

Nicholas Schaum

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia

Michael Seamus Haney, Róbert Pálovics, Christy Nicole Munson, Chris M. Long, Patrik K. Johansson, Oscar Yip, Wentao Dong, Eshaan S. Rawat, Elizabeth West, Johannes C. M. Schlachetzki, Andy Po‐Yi Tsai, Ian Hunter Guldner, Bhawika S. Lamichhane, Amanda Smith, Nicholas Schaum, , Tony Wyss‐Coray

The paper links APOE4/4 genotype to lipid droplet accumulation in Alzheimer's microglia, showing its role in neurotoxicity through triglyceride synthesis and Tau phosphorylation.

bioRxiv · Jul 21, 2023 · PreprintNeuroscience

The Tabula Sapiens: a multiple organ single cell transcriptomic atlas of humans

Robert C. Jones, Jim Karkanias, Mark A. Krasnow, Angela Oliveira Pisco, Stephen R. Quake, Julia Salzman, Nir Yosef, Bryan Bulthaup, Phillip Brown, William Harper, Marisa Hemenez, Ravikumar Ponnusamy, Ahmad Salehi, Bhavani A. Sanagavarapu, Eileen Spallino, , Andrea R. Yung

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

Science · May 12, 2022Peer-reviewedCell Biology

Molecular hallmarks of heterochronic parabiosis at single cell resolution

Róbert Pálovics, Andreas Keller, Nicholas Schaum, Weilun Tan, Tobias Fehlmann, Michael Borja, Fabian Kern, Liana N. Bonanno, Kruti Calcuttawala, James T. Webber, Aaron McGeever, Nicole Almanzar, Jane Antony, Ankit S. Baghel, Isaac Bakerman, , Rahul Sinha

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

Nature · Mar 2, 2022Peer-reviewedGenomics

Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19

Andrew C. Yang, Fabian Kern, Patricia Morán Losada, Maayan R. Agam, Christina A. Maat, Georges Pierre Schmartz, Tobias Fehlmann, Julian A. Stein, Nicholas Schaum, Davis P. Lee, Kruti Calcuttawala, Ryan T. Vest, Daniela Berdnik, Nannan Lu, Oliver Hahn, , Tony Wyss‐Coray

The paper analyzes single-nucleus transcriptomes from brain and choroid plexus tissues of COVID-19 and influenza patients, identifying broad transcriptional dysregulation in multiple cell types and linking these changes to neurological symptoms.

Nature · Jun 21, 2021Peer-reviewedNeuroscience

A human brain vascular atlas reveals diverse cell mediators of Alzheimer's disease risk

Andrew C. Yang, Ryan T. Vest, Fabian Kern, Davis P. Lee, Christina A. Maat, Patricia Morán Losada, Michelle B. Chen, Maayan R. Agam, Nicholas Schaum, Nathalie Khoury, Kruti Calcuttawala, Róbert Pálovics, Andrew Shin, Elizabeth Y Wang, Jian Luo, , Tony Wyss‐Coray

VINE-seq yields 143,793 single-nucleus transcriptomes of human brain vascular and perivascular cells; 30 of the top 45 Alzheimer's GWAS genes are expressed there, many microglial in mice.

bioRxiv · Apr 26, 2021 · PreprintNeuroscience