Author

Joana Figueiro‐Silva

University of ZurichORCID 0000-0003-3590-1784Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Ruxandra Bachmann-GagescuiD· 2 shared Affef AbidiiD· 1 shared Anita M. RauchiD· 1 shared Beatrice OnedaiD· 1 shared Fabian F. VoigtiD· 1 shared Fritjof HelmcheniD· 1 shared Kris VleminckxiD· 1 shared Melanie EschmentiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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10 top collaborators · 25 mutual co-author links

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2 shared papersDevelopmental Biology

Ruxandra Bachmann-GagescuORCID

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2 papers

Recent·Most cited

Developmental BiologyStem Cell ResearchPeer-reviewedSep 1, 2025

CRISPR/Cas9-mediated generation of two isogenic CEP290-mutated iPSC lines

Joana Figueiro‐Silva, Melanie Eschment, Michelle Mennel…·Ruxandra Bachmann-Gagescu

This study generates two isogenic CEP290-mutated iPSC lines using CRISPR/Cas9 for disease modeling of ciliopathies.

DOI 10.1016/j.scr.2025.103781

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyNature BiotechnologyPeer-reviewedAug 12, 2025

Pythia: Non-random DNA repair allows predictable CRISPR/Cas9 integration and gene editing

Thomas Naert, Taiyo Yamamoto, Shuting Han…·Soeren S. Lienkamp

The paper introduces Pythia, a tool that uses deep learning to predict CRISPR/Cas9 integration and editing outcomes by leveraging non-random DNA repair patterns.

7 citations

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