Shuting Han

The paper investigates how behavioral states modulate sensory processing across brain regions in mice during a choice task, identifying state-dependent differences in neural activity and information routing.

PURELIGHT improves photon efficiency and accuracy in fluorescence microscopy by recovering undistorted intensity and lifetime measurements at high count rates across multiple detector technologies.

This study identifies coordinated multi-level neural adaptations in mouse neocortical areas during task learning, showing increased neuronal responses, population-level changes, and inter-area interactions.

The paper introduces Pythia, a tool that uses deep learning to predict CRISPR/Cas9 integration and editing outcomes by leveraging non-random DNA repair patterns.

The paper identifies a distinct hypothalamus-habenula circuit that governs risk preference in economic decision-making.

This study investigates how the mouse neocortex resolves conflicting top-down predictions and bottom-up sensory inputs during behavior, showing hierarchical predictive coding in somatosensory and posterior parietal cortices.

The paper shows that dendritic responses in L5 pyramidal neurons during learning correspond to unsigned temporal difference error components, with salience signals aiding task learning.

The paper uses machine learning to identify and target cortical ensembles in mouse visual cortex, demonstrating the feasibility of closed-loop experiments with precise manipulation of functional ensembles.

The paper identifies subnetworks in mouse visual cortex that encode context of visual stimuli, showing distinct responses to deviant and redundant stimuli.

This study shows prolonged anesthesia in mice leads to cognitive impairment and altered synaptic turnover in the cortex, with increased synapse formation during anesthesia and loss afterward.

The paper investigates how sensory input and behavior influence signal routing in the neocortex during short-term memory tasks in mice.

The paper shows that activating specific pattern completion neurons in mouse visual cortex can improve or disrupt visual task performance, suggesting a causal role for neuronal ensembles in behavior.

This paper develops a dual-color two-photon microscope for 3D volumetric imaging of neural activity in awake mice, revealing new insights into cortical layer interactions and functional connectivity.

This study examines how medically-induced loss of consciousness affects cortical microstates and neuronal ensembles in mice and humans using imaging and electrophysiological data.