Owen F.J. Hovey

This study shows that inhibiting LIN28A with LIN28i-1632 enhances imatinib sensitivity in imatinib-resistant CML cells by reducing BCR-ABL abundance and disrupting the AKT survival pathway.

This study identifies triciribine's pleiotropic antimetabolite effects in ALL by showing its ADK-dependent activity and impact on multiple cellular pathways.

This study identifies LIN28A as a mediator of imatinib resistance in CML by reprogramming the kinome and phosphoproteome, with potential therapeutic implications for overcoming resistance.

This study isolates extracellular vesicles from minimal ascites fluid using strong anion exchange magnetic beads, enhancing proteomic depth and identifying new proteins and SERS signatures in ovarian cancer-derived EVs.

The paper identifies proteomic differences in urinary extracellular vesicles from pediatric nephrotic syndrome patients during active disease versus remission, linking them to podocyte injury.