Jason S. Carroll

The paper shows that eGATA3 mutations alter transcriptional regulation and lineage identity in luminal breast cancer without losing DNA-binding function.

This paper shows that IL-1-activated cancer-associated fibroblasts (iCAFs) promote STAT1-driven transcriptional reprogramming in pancreatic tumour cells, leading to chemoresistance and identifying STAT1 as a therapeutic target.

The paper compares ASCL1 interactomes in neuroblastoma cell lines to identify CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified cells.

The paper identifies a JAK2-HNRNPA1 pathway that represses retrotransposon activity in haematopoietic stem cells, reducing insertional mutagenesis.

EstroGene2.0 is a multi-omic database that compiles data on estrogen receptor responses and resistance in breast cancer, revealing diverse transcriptomic changes and identifying key targets.

This study uses iPSCs from autistic individuals to identify early neurodevelopmental differences during cortical and midbrain differentiation.

This study identifies ID4 as a repressor of myoepithelial differentiation in mammary stem cells through its interaction with HEB, using integrated transcriptomic, proteomic, and ChIP-sequencing data.

This study fine-maps 150 breast cancer risk regions to identify 178 high confidence target genes using genomic and functional annotations.

GenEditID is a platform for identifying CRISPR-edited cell clones using deep sequencing and proteomic data, enabling scalable and sensitive gene editing analysis.

This study identifies ID4's role in DNA damage response in BLBC and HGSOV by showing its interaction with MDC1 and DNA repair proteins, linking it to BRCA1-mutant tumors.