Trisomy 21 impairs synchronized activity and connectivity in developing human Down syndrome cortical excitatory neuron networks
Manuel Peter, Raquel Real, Alessio Strano…·Frederick J. Livesey
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Harvard UniversityORCID 0000-0003-3846-5412Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Manuel Peter, Raquel Real, Alessio Strano…·Frederick J. Livesey
Manuel Peter, Seth L. Shipman, Jeffrey D. Macklis
The paper tests fluorescent timer proteins to synchronize cortical progenitor cell differentiation from hPSCs but finds they fail to achieve synchronized fluorescence kinetics.
Linus Manubens-Gil, Zhi Zhou, Hanbo Chen…·Hanchuan Peng
BigNeuron benchmarks automatic neuron reconstruction algorithms using gold standard annotations and image quality metrics, showing that consensus methods outperform individual algorithms.
Manuel Peter, Dominik F. Aschauer, Renata Rose…·Simon Rumpel
This study shows that chromatin reorganizes at the nucleus scale in neurons in response to stimuli, enabling rapid transcriptional changes for memory consolidation.