Johannes U. Pfabe

This study shows that PFKFB3 inhibition restores β-cell Ca2+ signaling responsiveness to acetylcholine in 3xTg-AD pancreatic tissue slices.

This study maps spatial and functional states of human pancreatic cells in health and disease using combined single-cell and spatial transcriptomics with calcium imaging.

This study investigates how calorie restriction modulates beta cell Ca2+ homeostasis and network connectivity, finding that CR beta cells exhibit faster, shorter Ca2+ oscillations and reduced network connectivity.

This study shows presenilin-1 regulates glucose metabolism and beta cell identity by controlling calcium homeostasis in pancreatic islets.

This study investigates how arginine vasopressin (AVP) modulates alpha and beta cell activity in pancreatic tissue slices in a glucose-dependent manner, revealing bell-shaped concentration responses and receptor-specific effects.

The paper shows that cytosolic S100A8/A9 is essential for neutrophil adhesion under flow by regulating Ca2+ availability at LFA-1 adhesion clusters.