Marjan Slak Rupnik

PFKFB3 inhibition restores β-cell responsiveness to acetylcholine in a 3xTg-AD pancreatic tissue-slice mode

This study shows that PFKFB3 inhibition restores β-cell Ca2+ signaling responsiveness to acetylcholine in 3xTg-AD pancreatic tissue slices.

Spatial and functional mapping of the human pancreas reveals endocrine and exocrine cell states in health and metabolic disease

This study maps spatial and functional states of human pancreatic cells in health and disease using combined single-cell and spatial transcriptomics with calcium imaging.

Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells

The paper investigates functional heterogeneity and sex-dependent regulation of pancreatic α-cells by neighboring β- and δ-cells using calcium dynamics in mice.

Calorie Restriction modulates beta cell IP3R activity to regulate Ca2+ homeostasis and cell network connectivity

This study investigates how calorie restriction modulates beta cell Ca2+ homeostasis and network connectivity, finding that CR beta cells exhibit faster, shorter Ca2+ oscillations and reduced network connectivity.

Microvascular homeostasis is compromised in pancreatic islets in a mouse model of beta cell loss and low-grade inflammation

This study shows that pericyte dysfunction in pancreatic islets leads to vascular abnormalities and inflammation before diabetes onset in mice treated with streptozotocin.

Presenilin-1 controls glucose metabolism and identity of pancreatic beta cells

This study shows presenilin-1 regulates glucose metabolism and beta cell identity by controlling calcium homeostasis in pancreatic islets.

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

This study shows that beta cell dysfunction occurs in type 1 diabetes independently of T cell infiltration, using human pancreas tissue slices from recently diagnosed patients.

Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of Alpha and Beta Cell Activity

This study investigates how arginine vasopressin (AVP) modulates alpha and beta cell activity in pancreatic tissue slices in a glucose-dependent manner, revealing bell-shaped concentration responses and receptor-specific effects.

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.

Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment

The paper shows that cytosolic S100A8/A9 is essential for neutrophil adhesion under flow by regulating Ca2+ availability at LFA-1 adhesion clusters.