Author

Daniel T. Claiborne

The Wistar InstituteORCID 0000-0002-2091-1456Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alessio UgoliniiD· 1 shared Alexander M. PriceiD· 1 shared Alison YuiD· 1 shared Andrew V. KossenkoviD· 1 shared Brennah MurphyiD· 1 shared Bryan S. ManningiD· 1 shared Claire M O'Brien· 1 shared Clayton J. OtteriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Alessio UgoliniORCID

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2 papers

Recent·Most cited

Inhibition of RNA splicing is a novel therapeutic strategy for disruption of nuclear replicating viruses

Lorenzo Serra, Claire M O'Brien, Molly R. Patterson, Clayton J. Otter, Alison Yu, Reyes Acosta, Daniel T. Claiborne, Susan Reich Weiss, Alexander M. Price

This study shows that inhibiting RNA splicing reduces viral replication in splicing-dependent viruses like adenovirus, HSV-1, and influenza A, suggesting a new antiviral strategy.

bioRxiv · Jun 27, 2026 · PreprintMicrobiology

Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

Brennah Murphy, Taito Miyamoto, Bryan S. Manning, Gauri Mirji, Alessio Ugolini, Toshitha Kannan, Kohei Hamada, Yanfang Peipei Zhu, Daniel T. Claiborne, Lu Huang, Rugang Zhang, Yulia Nefedova, Andrew V. Kossenkov, Filippo Veglia, Rahul Suresh Shinde, Nan Zhang

The paper shows that intraperitoneal administration of β-glucan and IFNγ clears ascites and induces IL27-dependent tumor regression in metastatic ovarian cancer models.

The Journal of Experimental Medicine · Oct 16, 2024Peer-reviewedImmunology