Vladan Lučić

The paper uses cryo-correlative light and electron tomography to study dopamine and glutamatergic synaptosomes in the striatum of adult mice, revealing differences in vesicle organization and release readiness between the two types.

The paper introduces a parameter-free method for analyzing colocalization in cryo-electron tomograms to study spatial organization of protein complexes.

The paper uses AI classification and preprocessing to detect native SNARE and Munc13 protein bridges in cryo-ET data, revealing their role in synaptic vesicle tethering.

The paper uses cryo-electron tomography to study synaptic vesicle tethering and priming, revealing the role of Munc13 and SNAP25 in confining vesicles and guiding fusion.

The paper uses cryo-electron tomography to sequence events during synaptic vesicle exocytosis and identifies how tether formation and connector dissolution are regulated by stimulation and spontaneous fusion rate.

The paper uses cryo-electron tomography to visualize trans-synaptic assemblies linking synaptic vesicles and receptors, showing their precise organization and structure.