This study examines antibody responses to Shigella in Bangladeshi children, finding that younger children have less effective functional antibody responses against OSP and proteins, correlating with disease severity.

Cell Reports Medicine · Sep 24, 2026Peer-reviewedImmunology

Antibody Correlates of Resilience to Staphylococcus aureus Disease and Recurrence in Children

Mehak Zahoor Khan, Carol M. Kao, Wonyeong Jung, Thendral Selvam, Evgenii Kliuchnikov, Mary G. Boyle, Leslie A. Fogel, Jeanette T. Pingel, Jackie N Wright, Jonathon Chase McNeil, Kristina G. Hultén, Sheldon L. Kaplan, Laura Fontana, Douglas A. Lauffenburger, Galit Alter, , Boris Dominik Jülg

The paper profiles antibody responses in children to identify correlates of resilience to Staphylococcus aureus disease and recurrence, finding that functional antibodies and Fc receptor engagement are key protective factors.

bioRxiv · Jul 1, 2026 · PreprintImmunology

Distinct antibody-based signatures and functionality distinguish latent and active pediatric tuberculosis

Nadège Nziza, Wonyeong Jung, Tina Chen, Yixiang Deng, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Sarah Kiguli, Deborah A. Lewinsohn, W. Henry Boom, Harriet Mayanja‐Kizza, Mary Nsereko, Sarah M. Fortune, Catherine M. Stein, Ryan P. McNamara, Galit Alter, Christina Lancioni

The paper identifies distinct antibody-based signatures and functionalities in latent and active pediatric tuberculosis, highlighting differences in humoral immune responses that may inform diagnostic and therapeutic strategies.

bioRxiv · Jul 21, 2025 · PreprintImmunology

Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta

Krishna Kumar Ganta, Margaret M. McManus, Ross Blanc, Qixin Wang, Wonyeong Jung, Robin Brody, Mary N Carrington, Robert Paris, Sumana Chandramouli, Ryan P. McNamara, Katherine Luzuriaga

The paper investigates EBNA-1 specific antibodies in IM patients, finding persistent functional antibodies with cross-reactivity to CRYAB and association with MS risk alleles.

Cell Reports · May 1, 2025Peer-reviewedImmunology

Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron in Macaques

Xin Tong, Qixin Wang, Wonyeong Jung, Taras M. Chicz, Ross Blanc, Lily J. Parker, Dan H. Barouch, Ryan P. McNamara

This study identifies compartment-specific antibody correlates of protection against SARS-CoV-2 Omicron in macaques, showing neutralizing antibodies in serum and antibody-dependent cellular phagocytosis in bronchiolar lavage are strongest correlates.

iScience · Jun 5, 2024Peer-reviewedImmunology