Irina Kopyeva

This study uses adipose-mimetic hydrogels to show that soft mechanical cues from adipocytes enhance breast cancer cell invasion by altering ECM structure and cellular confinement.

This study shows that large adipocytes release lipids via extracellular vesicles, promoting breast cancer cell migration and proliferation, and links this to human dyslipidemia and triglyceride levels.

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

The paper introduces STOMP, a method to create multi-regional suspended tissues for studying complex tissue interfaces, and reports altered contractile dynamics in engineered heart tissues and bone-ligament constructs.

This paper introduces a hydrogel platform with reversible stiffness tuning and cell recovery capabilities to study mechanobiological effects on cell behavior and transcriptome responses.