Author

Despina Tsortouktzidis

University of BonnORCID 0000-0003-3753-7373Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Albert J. BeckeriD· 3 shared Anna R. TröscheriD· 2 shared Karen M. J. van LooiD· 2 shared Susanne SchochiD· 2 shared Alexander StumpfiD· 1 shared Alexej KnausiD· 1 shared Andreas GruberiD· 1 shared Anne VoigtiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Albert J. BeckerORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 13, 2025

HIF1α-dependent induction of the T-Type calcium channel CaV3.2 mediates hypoxia-induced neuronal hyperexcitability

Anna R. Tröscher, Despina Tsortouktzidis, Franziska Ammer-Pickhardt…·Karen M. J. van Loo

The paper identifies HIF1α as a regulator of CaV3.2 expression, linking hypoxia to neuronal hyperexcitability and epileptogenesis.

DOI 10.1101/2025.10.13.682038

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 20, 2021

A versatile CRISPR toolbox to study neurological CaV3.2 channelopathies by promoter-mediated transcription control

Despina Tsortouktzidis, Anna R. Tröscher, Herbert Schulz…·Karen M. J. van Loo

The paper demonstrates a CRISPRa/i toolbox for manipulating the Cacna1h gene promoter to study CaV3.2 channelopathies in neuronal cells and tissues.

1 citation

mouseCRISPR screen

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NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedJan 5, 2021

A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions

Miguel Rodríguez de los Santos, Marion Rivalan, Friederike Sophie David…·Peter Michael Krawitz

This paper introduces a CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency that mirrors human phenotypes, including cognitive impairments and epilepsy, and identifies synaptic transmission deficits.

15 citations

mouseexperimental assay

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