Karen M. J. van Loo

The paper identifies HIF1α as a regulator of CaV3.2 expression, linking hypoxia to neuronal hyperexcitability and epileptogenesis.

This study models AP2M1-DEE in Drosophila, finding heat-sensitive paralysis, altered neuron morphology, and seizure resistance, suggesting developmental defects over synaptic dysfunction.

This study analyzes human dendritic spine morphology and density using a unique dataset and deep learning, revealing sex and tissue-specific differences and changes over time in culture.

This study tracks neocortical development in organotypic mouse brain slice cultures over five weeks, revealing stable network properties by two weeks and increased variability later, with implications for disease research.

This paper provides a detailed protocol for long-term human organotypic brain slice cultures, enabling extended electrophysiological studies and viral transduction.

This study identifies SLK as critical for dendritic complexity and inhibitory synapse maintenance in neurons, with implications for human cortical malformations.

The paper demonstrates a CRISPRa/i toolbox for manipulating the Cacna1h gene promoter to study CaV3.2 channelopathies in neuronal cells and tissues.

This study identifies how PI3K/mTOR signaling and Trp53 loss determine the heterogeneity and excitability of BRAFV600E-induced brain tumors in mice.

This study identifies BCL11A as a defining transcription factor for a distinct subset of midbrain dopamine neurons, showing their vulnerability to Parkinson's disease and developmental roles in motor function.