Susanne Schoch

This study uses single-cell transcriptomics to show that BRAFV600E-driven glioneuronal tumors have distinct immune profiles based on tumor grade, with SPP1 playing a key role in high-grade tumors.

The paper identifies HIF1α as a regulator of CaV3.2 expression, linking hypoxia to neuronal hyperexcitability and epileptogenesis.

The paper develops a fluorescent biosensor (AGMsen) to visualize agmatine dynamics in cells, demonstrating its functionality across neuronal cultures.

The paper uses cryo-electron tomography to study synaptic vesicle tethering and priming, revealing the role of Munc13 and SNAP25 in confining vesicles and guiding fusion.

This study shows neuronal extracellular vesicles transfer microRNAs to mediate BDNF-dependent dendritogenesis and synapse maturation in hippocampal neurons.

This study examines the ultrastructural changes in active zones of RIM1α knock-out mice compared to wild-type, revealing altered synaptic vesicle organization and architecture.

This study identifies SLK as critical for dendritic complexity and inhibitory synapse maintenance in neurons, with implications for human cortical malformations.

The paper demonstrates a CRISPRa/i toolbox for manipulating the Cacna1h gene promoter to study CaV3.2 channelopathies in neuronal cells and tissues.

This study identifies how PI3K/mTOR signaling and Trp53 loss determine the heterogeneity and excitability of BRAFV600E-induced brain tumors in mice.

The paper investigates glutamate spread in the neuropil using optical reporters and finds that glutamate can activate AMPA and NMDA receptors at distances up to 2 micrometers from the release site.

The paper identifies daily oscillating transcripts in the hippocampus of control and epileptic mice, showing distinct circadian patterns and implications for drug timing.

The paper shows that in a mouse model of AD, memory recall is impaired due to the superimposition of new neurons onto the memory trace during retrieval.

The paper introduces variants of the glutamate sensor iGluSnFR with improved brightness, broader concentration detection, and different emission colors for enhanced in vivo imaging.