Carlo Maria Croce

This study uses the AID system with CRISPR/Cas9 to acutely degrade nucleolin in TNBC cells, revealing its role in cell cycle progression and division, and showing that its abrogation enhances the efficacy of mitotic inhibitors.

This study identifies miR-15b/16-2 as tumor suppressors in T-cell acute lymphoblastic leukemia by showing their role in inhibiting proliferation and promoting apoptosis through repression of BCL-2 and CYCLIN D3.

This study investigates miR-155 expression in leukemic stem cells and finds it regulates self-renewal and quiescence.

The paper introduces a new AID system that enables cell cycle-specific protein degradation, allowing study of protein roles in specific cell cycle phases.

MiREDiBase is a manually curated database of validated and putative miRNA editing events, including 3,059 sites from 626 pre-miRNAs in humans and three primates.