Peter Claus

This study enhances Fe-nitrogenase's ability to convert CO2 to hydrocarbons through directed evolution, increasing CH4 production and expanding the product spectrum to include ethane and CO.

This paper combines adaptive laboratory evolution and machine learning to engineer a methylsuccinate module for synthetic C1 metabolism in E. coli, achieving growth in three weeks versus six months with evolution alone.

The paper identifies COL1A1 as a translation-specific biomarker of SMA severity and shows it can be rescued by SMN-restoring therapies in multiple models.