Combining evolution and machine learning-guided pathway optimization to engineer a novel methylsuccinate module for synthetic C1 metabolism in vivo
Helena Schulz-Mirbach, Vittorio Rainaldi, Nitin Bohra, Katsutaka Suzuki, Titouan Danet, Huda Kasim, Ari Satanowski, Hai He, Elena Rossini, Seung Hwan Lee, Melanie Klose, Jörg Kahnt, Timo Glatter, Peter Claus, Nicole Paczia, , Tobias J. Erb
This paper combines adaptive laboratory evolution and machine learning to engineer a methylsuccinate module for synthetic C1 metabolism in E. coli, achieving growth in three weeks versus six months with evolution alone.
bioRxiv · Jan 20, 2026 · PreprintBioengineering