Author

Xiaozhen Hu

Moderna Therapeutics (United States)ORCID 0000-0003-3890-0533Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

William R. SchiefiD· 3 shared Alessia LiguoriiD· 2 shared Erik GeorgesoniD· 2 shared James C. PaulsoniD· 2 shared John R. YatesiD· 2 shared Jolene K. DiedrichiD· 2 shared Oleksandr KalyuzhniyiD· 2 shared Torben SchiffneriD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

William R. SchiefORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintNov 11, 2026

HIV broadly neutralizing antibody precursor maturation induced by mRNA vaccination in nonhuman primates

Ivy Phung, Brian L. Freeman, Alessia Liguori…·William R. Schief

This study shows that mRNA vaccines can prime and mature ultrarare HIV bnAb precursor B cells in NHPs, with improved affinity using a modified immunogen.

DOI 10.64898/2026.11.10.765717

non-human primateproteomics

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ImmunologybioRxivPreprintSep 16, 2025

mRNA-1273.251 and mRNA-1283.251 vaccines expressing SARS-CoV-2 variant LP.8.1 antigens broadly neutralize contemporary JN.1-lineage viruses

Arshan Nasir, Diana Wing Lee, Ziqiu Wang…·Alec W. Freyn

This study develops and evaluates two mRNA vaccines targeting the LP.8.1 variant of SARS-CoV-2, showing broad neutralization against JN.1-lineage subvariants.

1 citation

mouseexperimental assay

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ImmunologybioRxivPreprintJan 22, 2024

Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

Torben Schiffner, Anne L. Palser, Joseph G. Jardine…·William R. Schief

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

3 citations

mouseCITE-seq

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