Brendan D. Manning

This study shows dietary protein determines insulin's effect on hepatic mTORC1, and mTORC1 isn't elevated in diet-induced obesity despite metabolic impairments.

This study shows mTORC1 signaling promotes primary cilia elongation by suppressing autophagy, with effects observed in mouse neurons.

This study shows that AKT-mediated phosphorylation of TSC2 regulates tissue-specific mTORC1 signaling and organ growth in mice.