Yann Cormerais

This study shows dietary protein determines insulin's effect on hepatic mTORC1, and mTORC1 isn't elevated in diet-induced obesity despite metabolic impairments.

This study shows that deleting ferritin heavy chain in medulloblastoma cells limits tumor growth by promoting iron-dependent stress and sensitizing cells to iron toxicity.

This study shows mTORC1 signaling promotes primary cilia elongation by suppressing autophagy, with effects observed in mouse neurons.

This study identifies serine synthesis as a metabolic vulnerability in sunitinib-resistant renal cell carcinoma, showing that inhibiting key enzymes enhances drug sensitivity.

This study shows that AKT-mediated phosphorylation of TSC2 regulates tissue-specific mTORC1 signaling and organ growth in mice.