Author

Samuel C. Lapp

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Brendan D. ManningiD· 3 shared Krystle C. KalafutiD· 3 shared Madi Y. CisséiD· 3 shared Yann CormeraisiD· 3 shared Jong ShiniD· 2 shared Sandra Schrötter· 2 shared Angelica D’AmoreiD· 1 shared Benjamin Stefadu· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCell Biology

Brendan D. ManningORCID

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3 papers

Recent·Most cited

Dietary protein governs the role of insulin signaling in the postprandial regulation of hepatic mTORC1

Krystle C. Kalafut, Yann Cormerais, Madi Y. Cissé, Samuel C. Lapp, Karen Inouye, Gökhan S. Hotamışlıgil, Brendan D. Manning

This study shows dietary protein determines insulin's effect on hepatic mTORC1, and mTORC1 isn't elevated in diet-induced obesity despite metabolic impairments.

Nature Communications · Aug 31, 2026Peer-reviewedPhysiology

Growth Factor-Independent mTORC1 Signaling Promotes Primary Cilia Length via Suppression of Autophagy

Jong Shin, Khaled Tighanimine, Yann Cormerais, Dean M. Rosenthal, Pratima Niroula, Samuel C. Lapp, Krystle C. Kalafut, Madi Y. Cissé, Sandra Schrötter, Brendan D. Manning

This study shows mTORC1 signaling promotes primary cilia elongation by suppressing autophagy, with effects observed in mouse neurons.

iScience · Nov 25, 2025Peer-reviewedCell Biology

AKT-mediated phosphorylation of TSC2 controls stimulus and tissue-specific mTORC1 signaling and organ growth

Yann Cormerais, Samuel C. Lapp, Krystle C. Kalafut, Madi Y. Cissé, Jong Shin, Benjamin Stefadu, Jean Personnaz, Sandra Schrötter, Jessica Freed, Angelica D’Amore, Emma R. Martin, Catherine Lourdes Salussolia, Mustafa Şahin, Suchithra Menon, Vanessa Byles, Brendan D. Manning

This study shows that AKT-mediated phosphorylation of TSC2 regulates tissue-specific mTORC1 signaling and organ growth in mice.

Developmental Cell · Sep 23, 2024Peer-reviewedCell Biology