Adriano Biasini

This study identifies the essential role of Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis by showing their necessity for RNA degradation and preventing aberrant RNA accumulation.

The paper introduces a method to estimate RNA synthesis, processing, and degradation rates from a single sample in a single-pulse metabolic experiment, showing good correlation with published data.

The paper shows that A-MYB activates TCFL5, which is essential for meiosis and spermiogenesis in placental mammals, and its loss causes sterility.

The paper shows that translation is required for miRNA-dependent transcript decay, as non-translated lncRNAs are minimally affected by miRNA loss, while translated transcripts are destabilized.

The paper identifies cell cycle-associated lincRNAs in mouse embryonic stem cells and shows their role in cell cycle regulation and pluripotency maintenance.

The paper shows that elincRNA splicing is common and directly impacts enhancer function through cis-regulation.