Ana Claudia Marques

The paper introduces a method to estimate RNA synthesis, processing, and degradation rates from a single sample in a single-pulse metabolic experiment, showing good correlation with published data.

The paper investigates whether splicing of enhancer-associated long noncoding RNAs (elncRNAs) directly impacts enhancer function or is a consequence of enhancer activity, finding that splicing is associated with changes in chromatin signatures and target gene expression.

The paper analyzes lincRNA sequences across six eukaryotes to identify sequence signatures of repressed translation, finding shorter ORFs and suboptimal codon usage in species under strong selection.

This study provides guidelines for accurate SARS-CoV-2 genotyping using amplicon-based sequencing, showing that at least 1000 viral genomes are needed to reliably detect variants at 10% frequency.

The paper shows that translation is required for miRNA-dependent transcript decay, as non-translated lncRNAs are minimally affected by miRNA loss, while translated transcripts are destabilized.

This study shows TIP5 maintains genome compartmentalization in ground-state pluripotent stem cells by preventing active chromatin from invading repressive domains.

The paper identifies miRNA targets using an unbiased statistical approach and finds that noncanonical targeting contributes significantly to miRNA regulation.

This study investigates whether CAG/CTG repeat expansion alters chromatin folding using 4C sequencing and finds that chromatin contacts remain stable despite repeat expansion.

The paper identifies cell cycle-associated lincRNAs in mouse embryonic stem cells and shows their role in cell cycle regulation and pluripotency maintenance.

The paper shows that elincRNA splicing is common and directly impacts enhancer function through cis-regulation.