This study quantifies age-related changes in kidney extracellular matrix turnover and identifies structural and functional alterations linked to fibrosis.

1 citation

mouseproteomics

𝕏 PostBluesky

BiochemistrybioRxivPreprintApr 30, 2026

Label-free GAG disaccharide analysis by HILIC-MS/MS for studying diverse biological sample types

H Davies-Strickleton, George Taylor, James Allsey…·Douglas P. Dyer

The paper introduces a streamlined method for analyzing GAG disaccharides using HILIC-MS/MS, applicable to diverse biological samples.

1 citation

metagenomicsexperimental assay

𝕏 PostBluesky

Cell BiologyWellcome Open ResearchPeer-reviewedJul 30, 2025

Increased in vivo transduction of AAV-9 cargo in Alport podocytes

E. G. Williams, Maryline Fresquet, Gema Bolás…·Rachel Lennon

This study evaluates AAV9 transduction efficiency in Alport syndrome podocytes, finding enhanced transduction in Alport podocytes both ex vivo and in vivo.

DOI 10.12688/wellcomeopenres.24212.1

mouseexperimental assay

𝕏 PostBluesky

Developmental BiologybioRxivPreprintDec 14, 2024

A complete collagen IV fluorophore knock-in toolkit reveals -chain diversity in basement membrane

Sandhya Srinivasan, Willam Ramos-Lewis, Mychel Morais…·David R. Sherwood

The paper constructs a collagen IV fluorophore knock-in toolkit in C. elegans to study -chain diversity and basement membrane defects in collagen IV mutants.

DOI 10.1101/2024.12.14.628508

C. elegansexperimental assay

𝕏 PostBluesky