Author

Jithma P. Abeykoon

Mayo ClinicORCID 0000-0003-3939-6252Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alan D. D’AndreaiD· 2 shared Guangli Zhu· 2 shared Shuhei AsadaiD· 2 shared Sirisha MukkavalliiD· 2 shared Divya IyeriD· 1 shared Eliezer M. Van AlleniD· 1 shared Geoffrey Ira ShapiroiD· 1 shared Huy Nguyen· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Alan D. D’AndreaORCID

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2 papers

Recent·Most cited

Cancer BiologyMolecular CellPeer-reviewedJul 21, 2026

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

Shuhei Asada, Guangli Zhu, Jithma P. Abeykoon…·Alan D. D’Andrea

This paper shows that Ewing sarcoma cells have reduced POLθ expression and MMEJ activity due to EWS-FLI1 or EWSR1 disruption, making them sensitive to inhibitors of FA, NHEJ, or HR pathways.

5 citationstop 3%

humanDNA methylation

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Molecular BiologybioRxivPreprintNov 20, 2025

HPV16 E6 oncoprotein promotes microhomology-mediated viral integration by upregulating POLQ expression

Guangli Zhu, Shuhei Asada, Jithma P. Abeykoon…·Alan D. D’Andrea

This study shows HPV16 E6 oncoprotein increases POLQ levels via UBE3A and RAD23A regulation, enhancing MMEJ to promote viral integration and oncogenesis.

DOI 10.1101/2025.11.20.689626

humanDNA methylation

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