Author

Guangli Zhu

Dana-Farber Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alan D. D’AndreaiD· 2 shared Jithma P. AbeykooniD· 2 shared Shuhei AsadaiD· 2 shared Sirisha MukkavalliiD· 2 shared Divya IyeriD· 1 shared Eliezer M. Van AlleniD· 1 shared Geoffrey Ira ShapiroiD· 1 shared Huy Nguyen· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Alan D. D’AndreaORCID

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2 papers

Recent·Most cited

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

Shuhei Asada, Guangli Zhu, Jithma P. Abeykoon, Yutaro Tanaka, Huy Nguyen, Yuna Hirohashi, Divya Iyer, Nicholas William Ashton, Sirisha Mukkavalli, Martha Velazquez, Lige Jiang, Miles D. Del Busso, Judith Jebastin Thangaiah, Steven Ian Robinson, Kalindi Parmar, , Alan D. D’Andrea

This paper shows that Ewing sarcoma cells have reduced POLθ expression and MMEJ activity due to EWS-FLI1 or EWSR1 disruption, making them sensitive to inhibitors of FA, NHEJ, or HR pathways.

Molecular Cell · Jul 21, 2026Peer-reviewedCancer Biology

HPV16 E6 oncoprotein promotes microhomology-mediated viral integration by upregulating POLQ expression

Guangli Zhu, Shuhei Asada, Jithma P. Abeykoon, Lifang Sun, Sirisha Mukkavalli, Alan D. D’Andrea

This study shows HPV16 E6 oncoprotein increases POLQ levels via UBE3A and RAD23A regulation, enhancing MMEJ to promote viral integration and oncogenesis.

bioRxiv · Nov 20, 2025 · PreprintMolecular Biology