Sabine C Konings

The paper shows that neuronal age and ApoE4 genotype increase synaptic Aβ accumulation and alter its structural form in APPNL-F neurons.

This paper demonstrates the use of O-PTIR for fast, non-destructive spatiotemporal chemical analysis of unprocessed biopsies, living brain tissue, and vertebrates.

The paper shows that ApoE4 increases Aβ42 levels in neurons and demonstrates intracellular intersection of ApoE with APP/Aβ in AD transgenic neurons.

This study shows that APP and Aβ increase neuronal hyperexcitability and impair homeostatic synaptic and intrinsic plasticity in Alzheimer's disease models.

This study shows APOE4 disrupts calcium homeostasis in neurons, leading to sustained translation inhibition and impaired NMDAR signaling, while APOE3 causes a transient calcium response with recovery.