Alex M. Plum

This study identifies APLNR as a regulator of directed mesoderm migration in human gastruloids, showing chemotactic guidance through an epithelial ligand field.

The paper introduces a framework to analyze positional information in dynamic tissues and applies it to study cell mixing and pattern formation in developing embryos.

This paper develops a mathematical framework to study morphogen patterning in dynamic tissues, showing how cell movements influence morphogen transport, signaling ranges, and patterning outcomes.

This study develops a computational model of cooperative replicating polymer systems to explore how prebiotic environments with micro-compartments enable the persistence of cooperating polymers.

The paper quantifies cell flows during avian gastrulation using a Dynamic Morphoskeleton model and identifies the mechanistic roles of attractors and repellers in shaping the embryo.

This paper develops a mechanochemical model that explains vertebrate gastrulation morphologies by coupling actomyosin activity to tissue flow, showing how different patterns emerge from a uniform state.