Mattia Serra

APLNR regulates directed migration to spatially pattern mesoderm in human gastruloids

This study identifies APLNR as a regulator of directed mesoderm migration in human gastruloids, showing chemotactic guidance through an epithelial ligand field.

Coherent Structures in Active Flows on Dynamic Surfaces

This paper introduces a geometric framework to identify coherent structures in active flows on dynamic surfaces, revealing new transport patterns in biological systems.

Achiral Odd Mechanics in Cell Monolayers

This study develops a continuum model of cell monolayers using odd mechanics to account for nonequilibrium dynamics and broken symmetries, showing a nonzero odd viscous modulus in MDCK monolayers.

Positional information and information flows in dynamic tissues

The paper introduces a framework to analyze positional information in dynamic tissues and applies it to study cell mixing and pattern formation in developing embryos.

Morphogen Patterning in Dynamic Tissues

This paper develops a mathematical framework to study morphogen patterning in dynamic tissues, showing how cell movements influence morphogen transport, signaling ranges, and patterning outcomes.

Tissue geometry and mechanochemical feedback initiate rotational migration in Drosophila

The paper shows that rotational migration in Drosophila egg chambers is initiated by a feedback loop involving Fat2 and tissue geometry, revealing a biophysical mechanism for self-organized collective motion.

Activity-driven extracellular volume expansion drives vertebrate axis elongation

The paper shows that active tissue expansion, driven by FGF signaling and HA production, propels vertebrate body elongation without relying on cell proliferation.

Control of Modular Tissue Flows Shaping the Embryo in Avian Gastrulation

The paper quantifies cell flows during avian gastrulation using a Dynamic Morphoskeleton model and identifies the mechanistic roles of attractors and repellers in shaping the embryo.

Control of epiblast cell fate by mechanical cues

The paper identifies mechanical cues influencing epiblast cell fate in chicken embryos through single-cell RNA sequencing and lineage tracing.

A mechanochemical model recapitulates distinct vertebrate gastrulation modes

This paper develops a mechanochemical model that explains vertebrate gastrulation morphologies by coupling actomyosin activity to tissue flow, showing how different patterns emerge from a uniform state.

Zebrahub - Multimodal Zebrafish Developmental Atlas Reveals the State Transition Dynamics of Late Vertebrate Pluripotent Axial Progenitors

Zebrafish embryos sequenced individually across ten developmental stages, paired with light-sheet lineage reconstruction, form an atlas and browser for in silico fate mapping.

Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviours in the chick embryo

The paper manipulates cell behaviours in chick embryos to generate different gastrulation modes, suggesting evolution of these processes is shaped by mesendoderm territory shape and signalling pathways.

Dynamic Morphoskeletons in Development

The paper identifies Dynamic Morphoskeletons (DM) from cell velocity data to analyze tissue organization during development, revealing spatial attractors and repellers in chicken and fly embryos.