The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers
Francesco Tabaro, Basilia Acurzio, Aileen Julia Riesle, Monika Mielnicka, Camilla Lyons, Domenico M. Guarascio, Agnieszka Sadowska, Michela Ascolani, Marina Peralta, Emerald Perlas, Álvaro H. Crevenna, Neil E. Humphreys, Hiroki Asari, Mathieu Boulard
This study identifies TRIM66 as a key factor enforcing monogenic expression of olfactory receptors through epigenetic silencing of super-enhancers, impacting axonal projections and behavior.
bioRxiv · Dec 23, 2025 · PreprintMolecular Biology