Julien Vermot

Viscosity-mediated signal amplification enables robust left-right symmetry breaking in the mouse node

This study proposes a viscosity-mediated signal amplification model to explain left-right symmetry breaking in the mouse node by integrating mechanosensing and chemosensing.

Extracellular mechanical forces drive endocardial cell volume decrease during cardiac valve morphogenesis

The paper shows mechanical forces reduce endocardial cell volume during zebrafish cardiac valve formation through TRPP2/TRPV4 channels and hyaluronic acid.

Intraflagellar transport complex B proteins regulate the Hippo effector Yap1 during cardiogenesis

This study shows that IFT complex B proteins modulate YAP1 activity during cardiogenesis in zebrafish and mouse, linking cilia-related proteins to Hippo pathway regulation.

Mechanically activated Piezo channels control outflow tract valve development through Yap1 and Klf2-Notch signaling axis

This study identifies Piezo channels as central to OFT valve development by regulating Yap1, Klf2, and Notch signaling in response to mechanical forces in zebrafish.

Rere-dependent Retinoic Acid signaling controls brain asymmetry and handedness

The paper shows that Retinoic Acid signaling, specifically through Rere, controls brain asymmetry and handedness in zebrafish and mouse.

Chiral cilia orientation in the left-right organizer

The paper investigates cilia orientation asymmetry in the zebrafish left-right organizer and finds it is independent of left-right signaling and flow, instead relying on planar cell polarity.

Actomyosin dynamics, Bmp and Notch signaling pathways drive apical extrusion of proepicardial cells

The paper identifies actomyosin dynamics and Notch/Bmp signaling as drivers of apical extrusion of proepicardial cells in zebrafish during heart development.