Yi Shen

This paper develops excitation ratiometric fluorescent protein biosensors for citrate, enabling quantitative analysis of citrate dynamics in different cellular compartments and populations.

This paper introduces two new far-red fluorescent GECIs, FR-GECO1a and FR-GECO1c, characterized for their Ca2+ sensitivity and performance in neuronal imaging.

The paper develops T-GECO1, a blue-shifted genetically encoded Ca2+ indicator with enhanced two-photon brightness for improved neuronal activity imaging.

This paper develops improved photocleavable proteins with faster and more efficient dissociation for better optogenetic control.

The paper develops two high-performance genetically encoded biosensors for citrate imaging in mammalian cells, showing their ability to detect both steady-state and perturbed citrate concentrations.

This paper develops a FRET-based genetically encoded K+ indicator, KIRIN1, which detects K+ with high selectivity and enables real-time imaging in live cells.