Forebrain Shh overexpression improves cognitive function in a Down syndrome mouse model and euploid littermates
Feng Gao, Donna K. Klinedinst, Fabian‐Xosé Fernandez, Bei Cheng, Alena V. Savonenko, Benjamin Devenney, Yicong Li, Dan Wu, Martin G. Pomper, Roger H. Reeves
This study shows that overexpressing Shh in the forebrain of Down syndrome mice improves cognitive function, while cerebellar Shh overexpression does not.
Acta Neuropathologica Communications · Aug 16, 2021Peer-reviewedNeuroscience