Author

Lionel Le Gallic

Centre National de la Recherche ScientifiqueORCID 0000-0001-7147-9846Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Florence M. CammasiD· 2 shared Françis PoulatiD· 2 shared Stéphanie Le GrasiD· 2 shared Alain PruvostiD· 1 shared Anne‐Marie Lefrançois‐MartineziD· 1 shared Antoine MartineziD· 1 shared Antoine Vigier· 1 shared Anvi Laëtitia Nguyen· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPhysiology

Florence M. CammasORCID

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2 papers

Recent·Most cited

PKA disrupts adult ovarian identity circuits through direct inhibition of TRIM28-chromatin binding

Florian Chaleil, Lionel Le Gallic, Isabelle Sahut‐Barnola, Joris Mordier, Stéphanie Le Gras, Sylvain Roumeau, Céline Keime, Cyril Djari, Antoine Vigier, L. Badoil, Pierre Val, Jean‐Christophe Pointud, Constantine A. Stratakis, Florence M. Cammas, Antoine Martinez, , Anne‐Marie Lefrançois‐Martinez

This study shows PKA inhibits TRIM28-chromatin binding in ovarian granulosa cells, disrupting ovarian identity through SUMOylation dysregulation.

bioRxiv · Oct 7, 2026 · PreprintPhysiology

TRIM28-dependent SUMOylation protects the adult ovary from the testicular pathway

Moïra Rossitto, Stephanie Déjardin, Chris M. Rands, Stéphanie Le Gras, Roberta Migale, Mahmoud‐Reza Rafiee, Yasmine Neirijnck, Alain Pruvost, Anvi Laëtitia Nguyen, Guillaume Bossis, Florence M. Cammas, Lionel Le Gallic, Dagmar Wilhelm, Robin Howard Lovell-Badge, Brigitte Boizet‐Bonhoure, , Françis Poulat

This study identifies TRIM28's role in preventing female-to-male sex reversal in the adult mouse ovary by maintaining the ovarian pathway through SUMOylation.

Nature Communications · Jul 29, 2022Peer-reviewedDevelopmental Biology