Takashi Koyama

The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.

This study identifies saITP and Gyc76C as key regulators of water balance in Drosophila hindgut via a neuroendocrine axis.

The paper identifies transcription factors regulating the development of a unique beetle renal cell type involved in water conservation.

The paper shows that cytokine signaling from the Drosophila gut to brain glial cells regulates sleep, with oxidative stress-induced cytokines promoting sleep during intestinal inflammation.

The paper identifies NHA1 as a critical cation/proton antiporter in the rectal complex of Tribolium castaneum, essential for water conservation through ion transport and developmental regulation.

This study shows ecdysone coordinates plastic growth and robust pattern in Drosophila wings by regulating growth via graded responses and patterning via threshold responses to nutritional changes.

The paper shows ecdysone regulates antimicrobial peptide expression during Drosophila metamorphosis, linking hormonal signaling to immune function and bacterial control.

This study identifies myoglianin as a key factor linking muscle growth to metamorphosis initiation by assessing body size in insects.

The paper identifies a mechanism by which fat tissue senses oxygen levels and inhibits insulin secretion to regulate growth in Drosophila.

The paper identifies Torso-like as a secreted protein that regulates insulin signalling in Drosophila by modulating insulin-like peptide activity and developmental timing.

The paper shows that Lgr3 is required for Dilp8 signaling in Drosophila to coordinate growth with developmental timing by transmitting peripheral tissue stress signals to neuroendocrine centers.