Kim Rewitz

HR3/RORα-mediated cholesterol sensing regulates TOR signaling

The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.

Gut hormone signaling drives sex differences in metabolism and behavior

This study identifies gut hormone signaling as a driver of sex differences in metabolism and behavior in Drosophila, revealing conserved mechanisms across species.

Two-way pantothenate/nitrogen exchange reprograms fly metabolism and reinforces microbiota growth

This study shows Drosophila and their gut bacteria exchange pantothenate for nitrogen, reprogramming fly metabolism and supporting bacterial growth.

Ion transport peptide regulates body water balance via a receptor guanylyl cyclase in the Drosophila hindgut

This study identifies saITP and Gyc76C as key regulators of water balance in Drosophila hindgut via a neuroendocrine axis.

High-throughput assessment of exercise-induced adaptations and muscle function in health and ageing

The paper introduces ClimbMaster, an automated platform to assess exercise-induced adaptations in Drosophila, showing exercise improves endurance, fat loss, and insulin sensitivity, and rapamycin mitigates age-related decline.

Glia-mediated gut-brain cytokine signaling couples sleep to intestinal inflammation

The paper shows that cytokine signaling from the Drosophila gut to brain glial cells regulates sleep, with oxidative stress-induced cytokines promoting sleep during intestinal inflammation.

A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion

The paper identifies a mechanism by which fat tissue senses oxygen levels and inhibits insulin secretion to regulate growth in Drosophila.

AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance

This paper shows that AMPK signaling, disrupted by the 1q21.1 deletion, is essential for neuronal integrity, sleep maintenance, and stress survival in Drosophila.

Orchestration of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin

This study identifies the role of leucokinin (LK) neurons in coordinating post-feeding physiology and behavior in Drosophila by regulating water homeostasis, metabolism, and insulin signaling.