Author

Michael I. Barton

University of OxfordORCID 0000-0002-9263-6481Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Omer DushekiD· 2 shared P. Anton van der MerweiD· 2 shared Edward M. JenkinsiD· 1 shared Geoffrey J. BartoniD· 1 shared Jake BurtoniD· 1 shared Jesús A. Siller‐FarfániD· 1 shared Jose Cabezas-CaballeroiD· 1 shared Mikhail A. KutuzoviD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Omer DushekORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes

Jake Burton, Jesús A. Siller‐Farfán, Violaine André, Edward M. Jenkins, Michael I. Barton, Sofı́a Bustamante Eguiguren, Jose Cabezas-Caballero, Simon J. Davis, Thomas R. Weikl, P. Anton van der Merwe, Omer Dushek

The antigen sensitivity of CAR-T cells can be tuned to match the sensitivity of TCR-T cells by varying the relative extracellular size of CAR/antigen and CD2/CD58 complexes.

bioRxiv · Jan 6, 2025 · PreprintImmunology

Missense variants in human ACE2 modify binding to SARS-CoV-2 Spike

Stuart A. MacGowan, Michael I. Barton, Mikhail A. Kutuzov, Omer Dushek, P. Anton van der Merwe, Geoffrey J. Barton

The paper investigates how ACE2 missense variants affect SARS-CoV-2 Spike binding, identifying variants that enhance or inhibit binding and their potential impact on infection risk.

PLoS Computational Biology · Mar 2, 2022Peer-reviewedGenetics