Author

Thomas A. Down

GenentechORCID 0000-0002-6414-4586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:experimental assay· 2 Research Focus:software / tool· 2 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Organism:human· 1

Frequent Co-Authors

Kiran MukhyalaiD· 2 shared Mateusz WarownyiD· 2 shared Aaron Day-Williams· 1 shared Aileen Reghan FoleyiD· 1 shared Allan Daly· 1 shared Andrew P. JacksoniD· 1 shared Anna F. DominiczakiD· 1 shared Antonio CiampiiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBioinformatics

Kiran MukhyalaORCID

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Author profile →

3 papers

Recent·Most cited

Slivka and Slivka-bio: a lightweight framework for presenting executables as web services and its application in bioinformatics.

Mateusz Warowny, Thomas A. Down, Stuart A. MacGowan, Kiran Mukhyala, Geoffrey J. Barton, James B Procter

Slivka and Slivka-bio provide a lightweight framework for deploying bioinformatics tools as web services, enabling easy execution of code via HTTP and demonstrating with 15+ protein and RNA analysis tools.

bioRxiv · May 27, 2026 · PreprintBioinformatics

GYDE: A collaborative drug discovery platform for AI-powered protein design and engineering

Thomas A. Down, Mateusz Warowny, April Walker, Luigi D’Ascenzo, Donald Lee, Zhenru Zhou, Shengya Cao, Travis W. Bainbridge, John M. Nicoludis, Seth F. Harris, Kiran Mukhyala

GYDE provides an open-source platform for bench scientists to access AI tools for protein design and drug discovery through a collaborative interface.

bioRxiv · Mar 27, 2026 · PreprintBioinformatics

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Simon J. Haworth, Chin Yang Shapland, Caroline Hayward, Bram Peter Prins, Janine F. Felix, Carolina Medina‐Gómez, Fernando Rivadeneira, Carol A. Wang, Tarunveer S. Ahluwalia, Martine Vrijheid, Mònica Guxens, Jordi Sunyer, Ioanna Tachmazidou, Klaudia Walter, Valentina Iotchkova, , David K. Jackson

The paper identifies 9 novel genetic loci, including low-frequency variants in TP53, associated with head circumference and intracranial volume in up to 46,000 individuals.

Nature Communications · Jan 21, 2019Peer-reviewedGenetics