Taco W. A. Kooij

The paper identifies a silent intergenic locus in Plasmodium falciparum that allows stable transgene expression without disrupting native genes, enabling versatile genetic engineering.

The paper optimizes a transmission electron tomography workflow for malaria parasites and introduces VolWeaver to integrate high-resolution tomographic data into serial section volume reconstructions.

The paper uses photoaffinity labelling to investigate pantothenamide uptake differences between male and female malaria gametocytes, finding no significant uptake differences but potential subcellular localization variation.

The paper investigates the role of PfAMC1 in mitochondrial dynamics during Plasmodium falciparum host switching, showing its localization and impact on mitochondrial morphology.

This study identifies STOML as a mitochondrial protein in Plasmodium falciparum that forms a complex with FtsH metalloprotease, supporting its role in asexual blood-stage development.

This study identifies two MICOS components in malaria parasites and shows they are involved in crista junction organization but not initial cristae formation.

The paper develops an in vitro and in vivo platform for testing malaria transmission-blocking drugs using engineered Plasmodium falciparum gametocytes and humanized mice.

The paper determines the structure of the Pfs230:Pfs48/45 complex bound to transmission-blocking antibodies, revealing molecular interactions and epitopes that inform vaccine development.

This study details the division and segregation of mitochondria and apicoplasts in Plasmodium falciparum using imaging and microscopy techniques.

This study shows that AlbuMAX supplemented media increases the production of transmission-competent Plasmodium falciparum gametocytes compared to serum.

CompaCt integrates complexome profiling data across species to identify conserved and species-specific protein complexes and interactions, improving characterization through comparative analysis.

The paper identifies and validates a comprehensive list of mitochondrial proteins in Plasmodium falciparum using Bayesian statistics and experimental confirmation.

CEDAR provides a database for complexome profiling data with standardized formats, a web interface, and tools for analysis and exploration.