Eddie Rodríguez-Carballo

The paper shows that pluripotency factors in mESCs enhance firing of late DNA replication origins, altering the replication timing program without shortening S phase.

The paper shows that a chromatin boundary from the HoxD gene cluster can function independently of its genomic context when relocated in mouse development.

The paper identifies HOX13-mediated regulation of DBX2 in limb development and shows enhancers can cross TAD boundaries to regulate genes in different domains.

The paper investigates how chromatin topology affects the timing of enhancer function at the HoxD locus, finding that enhancer sequences can overcome adverse chromatin architecture to activate genes.

This study identifies a gene desert critical for Shox2 regulation and embryonic survival through enhancer networks in mouse development.

The paper investigates how chromatin domain structure affects Hox gene regulation, showing that enhancer activity and silencing marks are influenced by TAD boundaries and Polycomb complex recruitment.

The paper investigates the HoxD cluster's role as a dynamic TAD boundary in limb development, showing its resilience and ability to maintain regulatory segregation.