Tobias Meyer

This study shows YAP/TAZ control ERK dynamics to balance progenitor expansion and differentiation by modulating PPARG activation thresholds and Hippo signaling.

The paper shows that B-MYB/FOXM1 controls daughter cell fate by regulating mitotic E2F activity through timing of its activation during the cell cycle.

The paper shows YAP and mitogen signaling regulate the cyclin D1/p27 ratio during G1 phase, determining cell cycle entry or exit through receptor-mediated mechanisms and contact inhibition.

The paper shows that inactivation of CDK4/6, CDK2, and ERK in G1-phase is necessary for irreversible cell cycle exit and differentiation commitment during terminal cell differentiation.

This study identifies podocyte exopher-formation as a novel mechanism for removing antigen/autoantibody aggregates in membranous nephropathy, with potential for non-invasive monitoring.