Bodo Grimbacher

The microbiome determines the phenotype in CTLA-4 insufficient mice and men

This study shows that the microbiome influences disease severity in CTLA-4 insufficient mice and humans by altering immune responses and promoting inflammation.

Longitudinal Gut Microbiome Dynamics in Human CTLA-4 pathway Deficiencies: A One-Year Interventional Metagenomic Study

This study tracks gut microbiome changes in patients with CTLA-4 pathway deficiencies over one year of abatacept treatment, showing microbiome restructuring linked to disease improvement.

Activation of NF-κB signaling by optogenetic clustering of IKKα and β

The paper develops optogenetic tools to cluster eGFP-tagged proteins and uses them to activate NF-κB signaling by clustering IKKα and IKKβ.

Engineering Material Properties of Transcription Factor Condensates to Control Gene Expression in Mammalian Cells and Mice

This study tunes the material properties of transcription factor condensates to show their impact on gene expression levels in mammalian cells and mice.