Gordon Rix

This paper evolves noncanonical amino acid synthases in yeast to produce ncAAs from simple precursors, enabling scalable genetic code expansion.

This study presents a strategy using OrthoRep to evolve aminoacyl-tRNA synthetases in yeast, resulting in efficient incorporation of non-canonical amino acids into proteins.

This paper introduces a method to rapidly evolve genes in the lab, revealing new insights into enzyme adaptation that machine learning models cannot predict.

This paper develops a continuous directed evolution platform called OrthoRep to generate diverse enzyme variants with promiscuous activities by evolving TmTrpB through multi-mutation pathways.